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Major U.S. equities indexes fell Thursday as the Jackson Hole Economic Policy Symposium kicked off in Wyoming. Federal Reserve Chair Jerome Powell is scheduled to speak just after the markets open on Friday morning, and his remarks will be under the microscope as investors gauge the timing and magnitude of potential interest rate cuts.

The S&P 500 was down 0.9%, while the Dow slipped 0.4%. Underperformance from large tech stocks weighed on the Nasdaq, which dropped 1.7% on the day.

Shares of Moderna ( MRNA ) lost 6.5%, marking Thursday's weakest performance in the S&P 500. The share price drop coincided with the approval of Moderna's vaccine to protect against new strains of COVID-19. The Centers for Disease Control (CDC) recommends an updated shot for all people over the age of 6 months, and Moderna expects the new version to be available within a few days. However, at the beginning of August, the company lowered its full-year sales forecast , citing soft vaccine demand in Europe.

Intel ( INTC ) shares sank 6.1% following reports questioning the semiconductor giant's progress on the construction of two new chip fabrication plants in Germany. The company received a government subsidy of around $11 billion for the construction of the facilities, with the objective of having them online and producing chips by 2027. However, that schedule now appears uncertain. Some investors have expressed concerns that, as Intel targets significant cost reductions, the company may choose not to move forward with the plans in Germany.

Tesla ( TSLA ) Vice President Sreela Venkataratnam announced that she would be the latest in a string of executives to step down from the company, and shares of the electric vehicle (EV) manufacturer declined 5.7%. In an 11-year stint at Tesla, Venkataratnam was involved in constructing factories, accelerating vehicle production, and expanding the energy business.

Shares of investment manager Franklin Resources ( BEN ) added 4.6%, the best performance of any stock in the S&P 500. Thursday's gains reversed a portion of the heavy losses posted in the previous session after the firm said the co-chief investment officer (CIO) of its Western Asset Management unit was taking a leave of absence. The executive's exit came amid internal and regulatory investigations into certain past trade allocations at the division.

Nordson ( NDSN ), which provides coating and adhesive systems to various industries, reported better-than-expected sales and profits for its fiscal third quarter, and its shares advanced 3.3%. Momentum in the company's Industrial Precision Solutions segment, as well as sales growth in Asia-Pacific and Europe, helped drive the strong performance.

Shares of State Street ( STT ) ticked 2.2% higher as the financial services firm announced a partnership with the Swiss digital asset platform Taurus. The deal will help State Street provide reliable digital asset capabilities to its clients by leveraging Taurus' custody, tokenization, and node-management solutions.

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